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This drug is known to be substantially excreted by the kidneyand the risk of toxic reactions to this drug may be greater in patients with impaired renal functionBecause elderly patients are more likely to have decreased renal functioncare should be taken in dose selectionand it may be useful to monitor renal functionsee CLINICAL PHARMACOLOGY and DOSAGE AND ADMINISTRATION

Patients with a previous thromboembolic event and a family history of thromboembolic diseasepatients with thrombophiliashould use Cyklokapron only if there is a strong medical indication and under strict medical supervision.

Cases of allergic reaction with use of intravenous tranexamic acidincluding anaphylaxis or anaphylactoid reaction have been reported that are suggestive of a causal relationship.

There are no adequate and well-controlled studies in pregnant womenHowevertranexamic acid is known to pass the placenta and appears in cord blood at concentrations approximately equal to maternal concentrationBecause animal reproduction studies are not always predictive of human responsethis drug should be used during pregnancy only if clearly needed.

PRECAUTIONSBefore taking tranexamic acidtell your doctor or pharmacist if you are allergic to itor if you have any other allergiesThis product may contain inactive ingredientswhich can cause allergic reactions or other problemsTalk to your pharmacist for more details.This medication should not be used if you have certain medical conditionsBefore using this medicineconsult your doctor or pharmacist if you havecurrent blood clotse.gin the legslungsbraineyebleeding in the brainsubarachnoid hemorrhagecolor vision problems.Before using this medicationtell your doctor or pharmacist your medical historyespecially ofhistory of blood clotsa certain serious blood clotting problemdisseminated intravascular coagulation-DICkidney problemsincluding blood in the urineirregular menstrual bleeding of unknown cause.This drug may make you dizzyDo not driveuse machineryor do any activity that requires alertness until you are sure you can perform such activities safelyLimit alcoholic beverages.Kidney function declines as you grow olderThis medication is removed by the kidneysThereforethe elderly may be more sensitive to the effects of this drug.During pregnancythis medication should be used only when clearly neededDiscuss the risks and benefits with your doctor.This drug passes into breast milkConsult your doctor before breast-feeding.

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