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Zofran is the brand name for the generic drug ondansetron.

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Patients with underlying heart conditionssuch as congenital long QT syndrome Patient who are predisposed to low levels of potassium and magnesium in the blood Patients taking other medications that lead to QT prolongation.

Ondansetron does not itself appear to induce or inhibit the cytochrome P-450 drug-metabolizing enzyme system of the liversee CLINICAL PHARMACOLOGYBecause ondansetron is metabolized by hepatic cytochrome P450 drug-metabolizing enzymesCYP3A4CYP2D6CYP1A2inducers or inhibitors of these enzymes may change the clearance andhencethe half-life of ondansetronIn patients treated with potent inducers of CYP3A4i.ephenytoincarbamazepineand rifampinthe clearance of ondansetron was significantly increased and ondansetron blood concentrations were decreasedHoweveron the basis of available datano dosage adjustment for ZOFRAN is recommended for patients on these drugssee CLINICAL PHARMACOLOGY

The following adverse reactions have been reported in clinical trials of patients treated with ondansetronthe active ingredient of ZOFRANA causal relationship to therapy with ZOFRAN was unclear in many cases.

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