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In view of its pharmacologyknown interactions and side effectsparticular care should be observed when using danazol in patients with hepatic or renal diseasehypertension or other cardiovascular disease and in any state which may be exacerbated by fluid retention as well as in diabetes mellituspolycythaemiaepilepsylipoprotein disorderin those with a history of thrombosisand in those who have shown marked or persistent androgenic reaction to previous gonadal steroid therapyAdjustment in concomitant therapy may be called for particularly in patients with hypertensiondiabetes mellitus or epilepsy when introducing or discontinuing danazol as well as during Danazol treatment.
Take the missed dose as soon as you rememberSkip the missed dose if it is almost time for your next scheduled doseDo not take extra medicine to make up the missed dose.
3Inhibition of the mid-cycle surge of FSH and LH as well as alterations in the pulsatility of LHDanazol can also reduce the mean plasma levels of these gonadotrophins after the menopause.
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