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Digoxin is primarily excreted by the kidneysthereforepatients with impaired renal function require smaller than usual maintenance doses of digoxinsee DOSAGE AND ADMINISTRATIONBecause of the prolonged elimination half-lifea longer period of time is required to achieve an initial or new steady-state serum concentration in patients with renal impairment than in patients with normal renal functionIf appropriate care is not taken to reduce the dose of digoxinsuch patients are at high risk for toxicityand toxic effects will last longer in such patients than in patients with normal renal function.

LANOXIN is supplied as 125 mcg0.125-mgor 250 mcg0.25-mgtablets for oral administrationEach tablet contains the labeled amount of digoxin USP and the following inactive ingredientscorn and potato starcheslactoseand magnesium stearateIn additionthe dyes used in the 125 mcg0.125 mgtablets are D&C Yellow No10 and FD&C Yellow No6.

Digoxin showed no genotoxic potential in in vitro studiesAmes test and mouse lymphomaNo data are available on the carcinogenic potential of digoxinnor have studies been conducted to assess its potential to affect fertility.

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