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Brompheniramine, dextromethorphan, guaifenesin major because of the potential risk and severity of serotonin syndrome, caution should be observed when coadministering drugs that have serotonergic properties such as dextromethorphan and citalopram.
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TABLE 2Adverse Events Associated with Discontinuation of Treatment in Short-TermPlacebo-ControlledDepression Trials.
Do not stop using citalopram suddenlyor you could have unpleasant withdrawal symptomsAsk your doctor how to safely stop using this medicine.
In vitro studies suggest that citalopram is a relatively weak inhibitor of CYP2D6Coadministration of Celexa40 mg/day for 10 dayswith the TCA imipraminesingle dose of 100 mga substrate for CYP2D6did not significantly affect the plasma concentrations of imipramine or citalopramHoweverthe concentration of the imipramine metabolite desipramine was increased by approximately 50The clinical significance of the desipramine change is unknownNeverthelesscaution is indicated in the coadministration of TCAs with Celexa.
Citalopram can pass into breast milk and may harm a nursing babyYou should not breast-feed while you are using this medicine.
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vilazodone major due to the potential for serotonin syndrome, caution is advisable when combining selective serotonin reuptake inhibitors ssris such as citalopram with vilazodone.