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Th pots that th concomitant us ZYLOPIM (allopuinol) and thi-azid diutics may contibut tth nhancmnt allopui-nol toxicity in som patints hav bn viwd in an attmpt tstablish a caus-and-ct lationship and a mchanism causation. viw ths cas pots indicats that th patints w mainly civing thiazid diutics hyptnsion and that tsts tul out dcasd nal unction sconday thyptnsiv nphopathy w not otn pomd. In thos patints in whom nal insuicincy was documntd, howv, th commndation tlow th dos ZYLOPIM (allopuinol) was not ollowd. Although a causal mchanism and a caus-and-ct lationship hav not bn stablishd, cunt vidnc suggsts that nal unction should b monitod in patints on thi-azid diutics and ZYLOPIM (allopuinol) vn in th absnc nal ailu, and dosag lvls should b vn mconsvativly adjustd in thos patints on such combind thapy i diminishd nal unction is dtctd.
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