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The following events have been reported in patients being treated with doxazosin.

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Older adults may be more sensitive to the side effects of this drugespecially dizziness and low blood pressure when getting up from a sitting or lying positionThese side effects can increase the risk of falling.

Drug interactions may change how your medications work or increase your risk for serious side effectsThis document does not contain all possible drug interactionsKeep a list of all the products you useincluding prescription/nonprescription drugs and herbal productsand share it with your doctor and pharmacistDo not startstopor change the dosage of any medicines without your doctor’s approval.

Use with caution in liver disease or recent strokecerebrovascular accidentCVARule outprostate cancer before initiating therapy May cause first-dose fainting or sudden loss of consciousness Risk of dizziness upon standingdose dependentPotential for low blood pressuredry mouthand urinary complications in elderly Priapismpainful penile erectionsustained for hours and unrelieved by sexual intercourse or masturbationrarely reportedprobably less frequently than once in every several thousand patientswith alpha-1 antagonistsincluding doxazosinbecause condition can lead to permanent impotence if not promptly treatedpatients must be advised about seriousness of condition Concomitant use of other antihypertensivesadditive hypotensive effectsExtended-release form not indicated for high blood pressure Concomitant administration of immediate-release form with a phosphodiesterase-5PDE-5inhibitor can result in additive blood pressure lowering effects and symptomatichypotension May increase the risk of heart failure by exacerbating underlying myocardial dysfunction by beta-1Receptor stimulation with increases in renin and aldosterone.

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12 allhat showed that doxazosin, an alpha-adrenergic receptor blocker, had a higher incidence of heart failure events, and the doxazosin arm of the study was stopped.
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