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Do not increase your dose or use this drug more often or for longer than prescribedYour condition will not improve any fasterand your risk of side effects will increase.

The Patient Information LeafletPILis the leaflet included in the pack with a medicineIt is written for patients and gives information about taking or using a medicineIt is possible that the leaflet in your medicine pack may differ from this version because it may have been updated since your medicine was packaged.

SMA News Today is strictly a news and information website about the diseaseIt does not provide medical advicediagnosis or treatmentThis content is not intended to be a substitute for professional medical advicediagnosisor treatmentAlways seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical conditionNever disregard professional medical advice or delay in seeking it because of something you have read on this website.

Mestinonpyridostigmineis contraindicated in mechanical intestinal or urinary obstructionand particular caution should be used in its administration to patients with bronchial asthmaCare should be observed in the use of atropine for counteracting side effectsas discussed below.

SMA is a genetic neurodegenerative disease that involves impairment of the neuromuscular transmissionSo Mestinonwhich facilitates the nerve signal transmission at the neuromuscular junctionNMJby inhibiting acetylcholine breakdowncould be a potential therapy for SMA.

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