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Metoclopramide should not be used whenever stimulation of gastrointestinal motility might be dangerouse.gin the presence of gastrointestinal hemorrhagemechanical obstructionor perforation.
Metoclopramide should be discontinued in patients who develop signs or symptoms of TDThere is no known effective treatment for established cases of TDalthough in some patientsTD may remitpartially or completelywithin several weeks to months after metoclopramide is withdrawn.
Rarelycases of hepatotoxicitycharacterized by such findings as jaundice and altered liver function testswhen metoclopramide was administered with other drugs with known hepatotoxic potential.
If heartburn only occurs at certain timessuch as after the evening mealyour doctor may direct you to take a single dose before those times instead of taking it throughout the dayThis will reduce your risk of side effects.
Experience with esophageal erosions and ulcerations is limitedbut healing has thus far been documented in one controlled trial using q.i.dtherapy at 15 mg/doseand this regimen should be used when lesions are presentso long as it is toleratedsee ADVERSE REACTIONSBecause of the poor correlation between symptoms and endoscopic appearance of the esophagustherapy directed at esophageal lesions is best guided by endoscopic evaluation.
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