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President kennedy had addison s disease, and he was one of the first patients in the world to regularly use florinef as part of his treatment, because it was a very new drug at that time.

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Adequate animal reproduction studies have not been conducted with fludrocortisone acetateHowevermany corticosteroids have been shown to be teratogenic in laboratory animals at low dosesTeratogenicity of these agents in man has not been demonstratedIt is not known whether fludrocortisone acetate can cause fetal harm when administered to a pregnant woman or can affect reproduction capacityFludrocortisone acetate should be given to a pregnant woman only if clearly needed.

To avoid drug-induced adrenal insufficiencysupportive dosage may be required in times of stresssuch as traumasurgeryor severe illnessboth during treatment with fludrocortisone acetate and for a year afterwards.

The use of Florinef AcetateFludrocortisone Acetate Tablets USPin patients with active tuberculosis should be restricted to those cases of fulminating or disseminated tuberculosis in which the corticosteroid is used for the management of the disease in conjunction with an appropriate antituberculous regimenIf corticosteroids are indicated in patients with latent tuberculosis or tuberculin reactivityclose observation is necessary since reactivation of the disease may occurDuring prolonged corticosteroid therapy these patients should receive chemoprophylaxis.

Like all medicinesthis medicine can cause side effectsalthough not everybody gets them.

Infants born of mothers who have received substantial doses of fludrocortisone acetate during pregnancy should be carefully observed for signs of hypoadrenalism.

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