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In the APC trialthe hazard ratios compared to placebo for a composite endpointadjudicatedof cardiovascular deathmyocardial infarctionor stroke were 3.495CI 1.48.5with celecoxib 400 mg twice daily and 2.895CI 1.17.2with celecoxib 200 mg twice dailyCumulative rates for this composite endpoint over 3 years were 3.020/671 subjectsand 2.517/685 subjectsrespectivelycompared to 0.96/679 subjectswith placebo treatmentThe increases in both celecoxib dose groups versus placebo-treated patients were mainly due to an increased incidence of myocardial infarctionIn the PreSAP trialthe hazard ratio for this same composite endpointadjudicatedwas 1.295CI 0.62.4with celecoxib 400 mg once daily compared to placeboCumulative rates for this composite endpoint over 3 years were 2.321/933 subjectsand 1.912/628 subjectsrespectively.

Medicines are sometimes prescribed for purposes other than those listed in a Medication GuideDo not use NSAIDs for a condition for which it was not prescribedDo not give NSAIDs to other peopleeven if they have the same symptoms that you haveIt may harm them.

Stop taking your NSAID and call your healthcare provider right away if you get any of the following symptoms:

For JRAthe dosage for pediatric patientsage 2 years and olderis based on weightFor patients10 kg to 25 kg the recommended dose is 100 mg twice daily.

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