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Antiepileptic drugsincluding KEPPRAshould be withdrawn gradually to minimize the potential of increased seizure frequency.

KEPPRA is indicated as adjunctive therapy in the treatment of partial onset seizures in adults and children 1 month of age and older with epilepsy.

A saturable and stereoselective neuronal binding site in rat brain tissue has been described for levetiracetamExperimental data indicate that this binding site is the synaptic vesicle protein SV2Athought to be involved in the regulation of vesicle exocytosisAlthough the molecular significance of levetiracetam binding to SV2A is not understoodlevetiracetam and related analogs showed a rank order of affinity for SV2A which correlated with the potency of their antiseizure activity in audiogenic seizure-prone miceThese findings suggest that the interaction of levetiracetam with the SV2A protein may contribute to the antiepileptic mechanism of action of the drug.

The use of levetiracetam has been very rarely associated with acute kidney injurywith a time to onset ranging from a few days to several months.

Table 3 lists adverse reactions that occurred in at least 1of adult epilepsy patients receiving KEPPRA in placebocontrolled studies and were numerically more common than in patients treated with placeboIn these studieseither KEPPRA or placebo was added to concurrent AED therapy.

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