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Renal impairment clinical studies have shown that there is no significant drug accumulation in patients with renal impairment when they are treated with minocycline in the recommended doses.
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Therefore, it could be speculated that minocycline remains neurophysiologically efficacious even after a long-term.
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in addi- tion, minocycline prevents the fabrication of pro-inflammatory cytokines and no, and was recently shown to decrease microglial trafficking to injured neurons, supporting clinical util- ity.