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5Blood sugar In some people with HIV who use protease inhibitorslevels of sugarglucosein the blood become higher than normalProlonged bouts of higher-than-normal blood sugar levels may lead to diabetesalthough for the average personthe risk of developing this complication is lowRegular monitoring of your blood to assess sugar levels and other measurements will help you and your doctor be aware of changes that might suggest problems with your blood sugarAlthough the risk of developing diabetes is generally lowsymptoms that may be related to diabetesincreased thirstincreased urinationunexplained weight lossfatigue and dryitchy skinshould be discussed with your doctor.

CRIXIVAN Capsules are sensitive to moistureCRIXIVAN should be dispensed and stored in the original containerThe desiccant should remain in the original bottle.

Because of the complex regimens and side effects associated with the use of indinavirthis drug is rarely used in Canada and other high-income countriesStillif indinavir is prescribed in Canadahere is some information.

Acute hemolytic anemiaincluding cases resulting in deathhas been reported in patients treated with CRIXIVANOnce a diagnosis is apparentappropriate measures for the treatment of hemolytic anemia should be institutedincluding discontinuation of CRIXIVAN.

Carcinogenicity studies were conducted in mice and ratsIn miceno increased incidence of any tumor type was observedThe highest dose tested in rats was 640 mg/kg/dayat this dose a statistically significant increased incidence of thyroid adenomas was seen only in male ratsAt that dosedaily systemic exposure in rats was approximately 1.3 times higher than daily systemic exposure in humansNo evidence of mutagenicity or genotoxicity was observed in in vitro microbial mutagenesisAmestestsin vitro alkaline elution assays for DNA breakagein vitro and in vivo chromosomal aberration studiesand in vitro mammalian cell mutagenesis assaysNo treatment-related effects on matingfertilityor embryo survival were seen in female rats and no treatment-related effects on mating performance were seen in male rats at doses providing systemic exposure comparable to or slightly higher than that with the clinical doseIn additionno treatment-related effects were observed in fecundity or fertility of untreated females mated to treated males.

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