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If someone has overdosed and has serious symptoms such as passing out or trouble breathingcall 911Otherwisecall a poison control center right awayUS residents can call their local poison control center at 1-800-222-1222Canada residents can call a provincial poison control centerSymptoms of overdose may include muscle weakness or twitchingsevere stomach crampingslow or shallow breathingslow/fast/irregular heartbeatfaintingand seizures.
Medicines should not be disposed of via wastewater or household wasteAsk your pharmacist how to dispose of medicines no longer requiredThese measures will help to protect the environmentIf your tablets become discoloured or show any signs of deteriorationyou should seek the advice of your pharmacist.
In patients treated with potent CYP2D6 or CYP3A4 inhibitors dose reductions can be consideredsee section 4.5
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