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The recommended dosage of PLETAL is 100 mg twice daily taken at least half an hour before or two hours after breakfast and dinner.

The most frequent adverse reaction resulting in discontinuation of therapy in more than 3of patients treated with Pletal was headache50 mg twice daily1.3100 mg twice daily3.5and placebo0.3Other frequent causes of discontinuation included palpitation and diarrheaboth 1.1for Pletalall dosesversus 0.1for placebo.

Cardiovascularatrial fibrillationheart failuremyocardial infarctionnodal arrhythmiasupraventricular tachycardiaventricular extrasystolesventricular tachycardia.

There have been rare or very rare reports of haematological abnormalities including thrombocytopenialeucopeniaagranulocytosispancytopenia and aplastic anaemiasee section 4.8Most patients recovered on discontinuation of cilostazolHoweversome cases of pancytopenia and aplastic anaemia had a fatal outcome.

Figure 2Percent Mean Improvement in Maximal Walking Distance at Study End for the Eight RandomizedDouble-BlindPlacebo-Controlled Clinical Trials.

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