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When immuno-globulin g-sensitized bovine erythrocytes were exposed to a mouse macrophage cell line, tretinoin increased phagocytosis more than twofold at low concentrations 5 x 10-11m and higher when compared to controls.

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Once the acne lesions have responded satisfactorilyit may be possible to maintain the improvement with less frequent applicationsor other dosage forms.

Use caution in the sunWhen outsideeven on hazy daysareas treated with RETIN-A should be protectedAn effective sunscreen should be used any time you are outsideconsult your physician for a recommendation of an SPF level which will provide you with the necessary high level of protectionFor extended sun exposureprotective clothinglike a hatshould be wornDo not use artificial sunlamps while you are using RETIN-AIf you do become sunburnedstop your therapy with RETIN-A until your skin has recovered.

Sunscreen use is an essential aspect of hydroquinone therapy because even minimal sunlight exposure sustains melanocytic activity.

Every effort has been made to ensure that the information provided by Cerner MultumIncMultumis accurateup-to-dateand completebut no guarantee is made to that effectDrug information contained herein may be time sensitiveMultum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriateunless specifically indicated otherwiseMultum’s drug information does not endorse drugsdiagnose patients or recommend therapyMultum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement toand not a substitute forthe expertiseskillknowledge and judgment of healthcare practitionersThe absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safeeffective or appropriate for any given patientMultum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum providesThe information contained herein is not intended to cover all possible usesdirectionsprecautionswarningsdrug interactionsallergic reactionsor adverse effectsIf you have questions about the drugs you are takingcheck with your doctornurse or pharmacist.

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if they are pigmented patches is skin then hydro quinine used regularly along with retin a tretinoin will help fade the spots and give your skin a refreshed look.

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