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Theophylline has two distinct actions in the airways of patients with reversible obstructionsmooth muscle relaxationi.ebronchodilationand suppression of the response of the airways to stimulii.enon-bronchodilator prophylactic effectsWhile the mechanisms of action of theophylline are not known with certaintystudies in animals suggest that bronchodilatation is mediated by the inhibition of two isozymes of phosphodiesterasePDE III andto a lesser extentPDE IVwhile non-bronchodilator prophylactic actions are probably mediated through one or more different molecular mechanismsthat do not involve inhibition of PDE III or antagonism of adenosine receptorsSome of the adverse effects associated with theophylline appear to be mediated by inhibition of PDE IIIe.ghypotensiontachycardiaheadacheand emesisand adenosine receptor antagonisme.galterations in cerebral blood flow
Take this medicine exactly as directed by your doctorDo not take more of it and do not take it more often than your doctor orderedThis medicine works best if there is a constant amount in the bloodTo keep the blood level constanttake this medicine at the same time each day and do not miss any doses.
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicinesAlso tell your health care professional if you have any other types of allergiessuch as to foodsdyespreservativesor animalsFor non-prescription productsread the label or package ingredients carefully.
Do not crush or chew the capsules or tabletsDoing so can release all of the drug at onceincreasing the risk of side effectsAlsodo not split the tablets unless they have a score line and your doctor or pharmacist tells you to do soSwallow the whole or split tablet without crushing or chewing.
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