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Do not increase your dose or use this drug more often or for longer than prescribedYour condition will not improve any fasterand your risk of side effects will increase.

The Patient Information LeafletPILis the leaflet included in the pack with a medicineIt is written for patients and gives information about taking or using a medicineIt is possible that the leaflet in your medicine pack may differ from this version because it may have been updated since your medicine was packaged.

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Mestinonpyridostigmineis contraindicated in mechanical intestinal or urinary obstructionand particular caution should be used in its administration to patients with bronchial asthmaCare should be observed in the use of atropine for counteracting side effectsas discussed below.

SMA is a genetic neurodegenerative disease that involves impairment of the neuromuscular transmissionSo Mestinonwhich facilitates the nerve signal transmission at the neuromuscular junctionNMJby inhibiting acetylcholine breakdowncould be a potential therapy for SMA.

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